Drug name: Tabex
Active ingredient: Cytisine 1.5mg
Tabex is an anti-smoking medication which contains natural alkaloid – Cytisine. Cytisine belongs to a group of medicines called H-cholinomimetics (stimulants of N-cholinergic receptors). It is an alkaloid extracted from the plant Cytisus laburnum L. Or Thermopsis lanceolata R.Br. Cytisine is a lightly yellowish crystalline powder, easily soluble in water, ethanol and chloroform.
Cytisine action mechanism is similar to nicotine, however, it possesses a wider therapeutic action.
Cytisine also exerts analeptic and hypertensive effect. It stimulates the ganglia of autonomic nervous system, helps increase the secretion of epinephrine by the adrenal glands. Simultaneous excitation of the sympathetic ganglia and adrenal gland leads to increase of blood pressure.
Tabex (cytisine) reacts with N-cholinergic receptors of the carotid glomeruli causing short-term reflective stimulation of the respiratory center in the medulla oblongata. The action of cytisine on the breath has a short-term “jerky” character, however, in some cases, especially in reflective stop of breathing, cytisine can cause permanent recovery of respiration and circulation.
Tabex (Cytisine) plays an important role as a nicotine replacement substance. Tabex helps decrease nicotine addiction and facilitates manifestation of withdrawal symptoms associated with smoking cessation.
While smoking the effect of Cytisine is summarized with the effect of nicotine, leading to unpleasant symptoms of nicotine overdose. This ultimately helps patients gradually give up smoking without experiencing withdrawal symptoms.
Tabex clinical indication
Tebex tablets are prescribed to help people quit smoking. It facilitates withdrawal symptoms associated with smoking cessation.
The first treatment period of Tabex lasts 3 days. People should take 1 tablet of Tabex 6 times daily (every 2 hours) with the parrarel reducing the amount of cigarettes. In absence of therapeutic action, the treatment should be stopped.
In positive results (within the first 3 days of treatment) the treatment should be continued using the following scheme:
Period of treatment
Frequency of use
4 – 12 days
1 tablets every 2.5 hours
1 tablets every 3 hours
1 tablets every 5 hours
1 tablets every 6-8 hours
Smoking should be completely stopped not later than 5th from the beginning of treatment with Tabex pills.
Tabex drug contraindication
Tabex (cytisine) pills are contraindicated for use in the following conditions:
- Reactions of hypersensitivity to Tabex (cytisine)
- Hypertension stage II-III;
- Acute myocardial infarction;
- Unstable angina;
- History of cardiovascular diseases
- Severe bleeding
- Pulmonary edema;
- Peptic ulcer and duodenal ulcer in acute phase;
- Pregnancy and breastfeeding. (Tabex can causes damages to the fetus)
Tabex should be used with caution in the following condtions:
- Adrenal tumors;
- Gastroesophageal reflux;
- Chronic heart failure;
- Cerebrovascular disease;
- Peptic ulcer and duodenal ulcer in remission;
- Diabetes mellitus;
- Renal or hepatic impairment;
- Age under 18 and over 65 years.
To obtain a positive result from Tabex it is necessary that the smoker had a serious desire to quit smoking.
Patients should be warned that the use of cytisine on the background of continued smoking may lead to nicotine toxicity.
Tabex use should be monitored by a health care provider.
Tabex side effects
Tabex is usually well tolerated and does not cause any significant side effects:
Gastrointestinal tract: changes appetite, xerostomia, stomach pain, nausea, constipation, diarrhea.
CNS: headache, dizziness, insomnia, drowsiness, irritability.
Cardiovascular system: palpitations, increase of blood pressure, increased heart rate, chest pain, shortness of breath.
Other: myalgia, weight loss, increased sweating, and allergic reactions.
If you experience these or other Tabex side effects, make sure to let your doctor know.
Tabex drug interactions
Tabex tablets should not be combined with antituberculous drugs
Tabex pills need to be stored in protected from light place out of reach of children at a temperature 15-25°C.